Article
BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2013
Mar Victoria J, Wong Stephen Q, Li Jason, Scolyer Richard A, McLean Catriona, Papenfuss Anthony T, Tothill Richard W, Kakavand Hojabr, Mann Graham J, Thompson John F, Behren Andreas, Cebon Jonathan S, Wolfe Rory, Kelly John W, Dobrovic Alexander, McArthur Grant A
Abstract excerpt
PURPOSE: The mutation load in melanoma is generally high compared with other tumor types due to extensive UV damage. Translation of exome sequencing data into clinically relevant information is therefore challenging. This study sought to characterize mutations identified in primary cutaneous melanomas and correlate these with clinicopathologic features. EXPERIMENTAL DESIGN: DNA was extracted from 34 fresh-frozen...
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