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Article

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families.

Translational psychiatry - 21 Jul 2022

Ahangari Mohammad, Gentry Amanda E, Nguyen Tan-Hoang, Kirkpatrick Robert, Verrelli Brian C, Bacanu Silviu-Alin, Kendler Kenneth S, Webb Bradley T, Riley Brien P

Abstract excerpt

Multiplex families have higher recurrence risk of schizophrenia compared to the families of sporadic cases, but the source of this increased recurrence risk is unknown. We used schizophrenia genome-wide association study data (N = 156,509) to construct polygenic risk scores (PRS) in 1005 individuals from 257 multiplex schizophrenia families, 2114 ancestry-matched sporadic cases, and 2205 population controls, to...

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Identifiers

PMID: 35864105
DOI: 10.1038/s41398-022-02060-3
PMCID: PMC9304393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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