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Article

Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas.

Journal of neuropathology and experimental neurology - 16 Aug 2022

Mo Huan, Magaki Shino, Deisch Jeremy K, Raghavan Ravi

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutant gliomas are associated with a better prognosis in comparison to adult IDH wild-type glioma and glioma-CpG island methylator phenotypes. Although OLIG2 is mainly expressed in oligodendrocytes in normal adult brain, it is expressed in both astrocytomas and oligodendrogliomas. Utilizing the clinical, DNA methylation, and RNA-sequencing data from the Cancer Genome Atlas (TCGA)...

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Identifiers

PMID: 35856894
DOI: 10.1093/jnen/nlac059
PMCID: PMC9614687

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