Article
Isocitrate Dehydrogenase Mutant Grade II and III Glial Neoplasms.
Hematology/oncology clinics of North America - 1 Feb 2022
Mellinghoff Ingo K, Chang Susan M, Jaeckle Kurt A, van den Bent Martin
Abstract excerpt
Mutations in isocitrate dehydrogenase (IDH) 1 or IDH2 occur in most of the adult low-grade gliomas and, less commonly, in cholangiocarcinoma, chondrosarcoma, acute myeloid leukemia, and other human malignancies. Cancer-associated mutations alter the function of the enzyme, resulting in production of R(-)-2-hydroxyglutarate and broad epigenetic dysregulation. Small molecule IDH inhibitors have received regulatory...
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