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Article

PARP14 is a novel target in STAT6 mutant follicular lymphoma

18 Jul 2022

Abstract excerpt

Abstract The variable clinical course of follicular lymphoma (FL) is determined by the molecular heterogeneity of tumor cells and complex interactions within the tumor microenvironment (TME). IL-4 producing follicular helper T cells (TFH) are critical components of the FL TME. Binding of IL-4 to IL-4R on FL cells activates JAK/STAT signaling. We identified STAT6 mutations (STAT6MUT) in 13% of FL (N = 33/258), all...

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PMID: 35851155
DOI: 10.1038/s41375-022-01641-x

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