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Article

Molecular insights into the immunopathogenesis of follicular lymphoma.

Immunology today - 1 Jun 2000

Stamatopoulos K, Kosmas C, Belessi C, Stavroyianni N, Kyriazopoulos P, Papadaki T

Abstract excerpt

Follicular lymphoma is caused by the transformation of a germinal-center-derived B cell with a t(14;18) chromosomal translocation. The distribution of somatic mutations within immunoglobulin genes indicates that follicular-lymphoma cells can interact with antigen. In addition, nonimmunoglobulin genes such as BCL6 seem to undergo somatic hypermutation. Here, Kostas Stamatopoulos and colleagues relate the molecular...

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Share to B-Lymphocyte Subsets
Share to DNA Nucleotidyltransferases
Share to Embryonal Carcinoma Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

Share to Immunoglobulin kappa-Chains

Share to Lymphoma, Follicular

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Share to VDJ Recombinases

Source

Identifiers

PMID: 10825742
DOI: 10.1016/s0167-5699(00)01650-9

Genes

BCL6
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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