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Article

Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation.

Blood - 20 Jul 2017

Schmidt Janine, Ramis-Zaldivar Joan Enric, Nadeu Ferran, Gonzalez-Farre Blanca, Navarro Alba, Egan Caoimhe, Montes-Mojarro Ivonne Aidee, Marafioti Teresa, Cabeçadas Jose, van der Walt Jon, Dojcinov Stefan, Rosenwald Andreas, Ott German, Bonzheim Irina, Fend Falko, Campo Elias, Jaffe Elaine S, Salaverria Itziar, Quintanilla-Martinez Leticia

Abstract excerpt

Pediatric-type follicular lymphoma (PTFL) is a B-cell lymphoma with distinctive clinicopathological features. Recently, recurrent genetic alterations of potential importance for its pathogenesis that disrupt pathways associated with the germinal center reaction (TNFRSF14, IRF8), immune escape (TNFRSF14), and anti-apoptosis (MAP2K1) have been described. In an attempt to shed more light onto the pathogenesis of...

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Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Follicular

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Source

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Identifiers

PMID: 28533310
DOI: 10.1182/blood-2017-03-776278
PMCID: PMC5520474

Genes

TNFRSF14

Provenance

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