Article
Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.
Cancer research - 15 Nov 2010
Cheung K-John J, Johnson Nathalie A, Affleck Joslynn G, Severson Tesa, Steidl Christian, Ben-Neriah Susana, Schein Jacqueline, Morin Ryan D, Moore Richard, Shah Sohrab P, Qian Hong, Paul Jessica E, Telenius Adele, Relander Thomas, Lam Wan, Savage Kerry, Connors Joseph M, Brown Carolyn, Marra Marco A, Gascoyne Randy D, Horsman Douglas E
Abstract excerpt
Clinical correlative studies have linked 1p36 deletions with worse prognosis in follicular lymphoma (FL). In this study, we sought to identify the critical gene(s) in this region that is responsible for conferring inferior prognosis. BAC array technology applied to 141 FL specimens detected a minimum region of deletion (MRD) of ∼97 kb within 1p36.32 in 20% of these cases. Frequent single-nucleotide...
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