Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease.

doi:10.1182/bloodadvances.2020002944

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Article

Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease.

Blood advances - 24 Nov 2020

Nann Dominik, Ramis-Zaldivar Joan Enric, Müller Inga, Gonzalez-Farre Blanca, Schmidt Janine, Egan Caoimhe, Salmeron-Villalobos Julia, Clot Guillem, Mattern Sven, Otto Franziska, Mankel Barbara, Colomer Dolors, Balagué Olga, Szablewski Vanessa, Lome-Maldonado Carmen, Leoncini Lorenzo, Dojcinov Stefan, Chott Andreas, Copie-Bergman Christiane, Bonzheim Irina, Fend Falko, Jaffe Elaine S, Campo Elias, Salaverria Itziar, Quintanilla-Martinez Leticia

Abstract excerpt

Fifty-five cases of t(14;18)- follicular lymphoma (FL) were genetically characterized by targeted sequencing and copy number (CN) arrays. t(14;18)- FL predominated in women (M/F 1:2); patients often presented during early clinical stages (71%), and had excellent prognoses. Overall, t(14;18)- FL displayed CN alterations (CNAs) and gene mutations carried by conventional t(14;18)+ FL (cFL), but with different...

Topics

Child
DNA Copy Number Variations
Female
Humans
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Follicular
Mutation

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PMID: 33211828
DOI: 10.1182/bloodadvances.2020002944
PMCID: PMC7686888

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