Article
Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk.
Nature communications - 9 Nov 2022
Wang Xuehai, Nissen Michael, Gracias Deanne, Kusakabe Manabu, Simkin Guillermo, Jiang Aixiang, Duns Gerben, Sarkozy Clementine, Hilton Laura, Chavez Elizabeth A, Segat Gabriela C, Wong Rachel, Kim Jubin, Aoki Tomohiro, Islam Rashedul, May Christina, Hung Stacy, Tyshchenko Kate, Brinkman Ryan R, Hirst Martin, Karsan Aly, Freeman Ciara, Sehn Laurie H, Morin Ryan D, Roth Andrew J, Savage Kerry J, Craig Jeffrey W, Shah Sohrab P, Steidl Christian, Scott David W, Weng Andrew P
Abstract excerpt
Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk of transformation to more aggressive histology over time. Recurrent mutations associated with transformation have been identified; however, prognostic features that can be discerned at diagnosis could be clinically useful. We present here comprehensive profiling of both tumor and immune compartments in 155 diagnostic FL...
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