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Article

Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events.

Atherosclerosis - 1 Aug 2022

Al-Sharify Dania, Nielsen Signe Holm, Matthes Frank, Tengryd Christoffer, Sun Jiangming, Genovese Federica, Karsdal Morten A, Nilsson Jan, Goncalves Isabel, Edsfeldt Andreas

Abstract excerpt

BACKGROUND AND AIMS: Extracellular matrix (ECM) remodeling is one of the key components in the formation of vulnerable atherosclerotic plaques and cardiovascular events. We recently showed that the full-length ECM-proteoglycan osteoglycin was associated with plaque vulnerability and future cardiovascular events. In the present study, we aimed to investigate the association of cleaved osteoglycin with plaque...

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PMID: 35850021
DOI: 10.1016/j.atherosclerosis.2022.06.1025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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