Article
Assessment of the genetic effects of polymorphisms in the osteoprotegerin gene, TNFRSF11B, on serum osteoprotegerin levels and carotid plaque vulnerability.
Stroke - 1 Nov 2011
Straface Giuseppe, Biscetti Federico, Pitocco Dario, Bertoletti Giovanni, Misuraca Maria, Vincenzoni Claudio, Snider Francesco, Arena Vincenzo, Stigliano Egidio, Angelini Flavia, Iuliano Luigi, Boccia Stefania, de Waure Chiara, Giacchi Francesco, Ghirlanda Giovanni, Flex Andrea
Abstract excerpt
BACKGROUND AND PURPOSE: Osteoprotegerin (OPG) is a secretory glycoprotein which belongs to the tumor necrosis factor receptor family. Various mechanisms have been suggested by which calcification might alter atherosclerotic plaque stability, but the significance of this intimal calcification is controversial. High concentrations of OPG have been associated with the presence of vascular and cardiovascular...
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