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Article

Proteomics and ex vivo plaque culture identify the insulin-like growth factor axis as a potential regulator of matrix remodelling in carotid plaques.

Atherosclerosis - 1 May 2026

Jørgensen Sara M, Yang-Jensen Karen C, Yeung Karin, Khare Harshvardhan A, Dawoodi Ida M, Kjær Andreas, Resch Timothy A, Eiberg Jonas P, Davies Michael J, Lorentzen Lasse G

Abstract excerpt

BACKGROUND AND AIMS: Rupture of carotid atherosclerotic plaques is a significant cause of stroke. We have previously analyzed 21 plaques by mass spectrometry and reported differing proteomic profiles between morphologically unstable (rupture-prone) and stable plaques. This expanded dataset includes additional carotid plaques as well as non-atherosclerotic arteries, allowing comparison with control tissue....

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Share to Carotid Arteries
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Proteins

Share to Insulin-Like Growth Factor II

Share to Plaque, Atherosclerotic

Share to Receptor, IGF Type 1

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Share to Rupture, Spontaneous

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Identifiers

PMID: 42001536
DOI: 10.1016/j.atherosclerosis.2026.120734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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