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Article

Increased expression of the transforming growth factor-beta signaling pathway, endoglin, and early growth response-1 in stable plaques.

Stroke - 1 Feb 2009

Bot Pieter T G, Hoefer Imo E, Sluijter Joost P G, van Vliet Patrick, Smits Anke M, Lebrin Franck, Moll Frans, de Vries Jean-Paul, Doevendans Pieter, Piek Jan J, Pasterkamp Gerard, Goumans Marie-José

Abstract excerpt

BACKGROUND AND PURPOSE: Unstable atherosclerotic plaques are characterized by increased macrophages and reduced smooth muscle cells (SMCs) and collagen content. Endoglin, an accessory transforming growth factor-beta (TGFbeta) receptor, is a modulator of TGFbeta signaling recently found to be expressed on SMCs in atherosclerotic plaques. Its function in plaque SMCs and plaque development is unknown. Early growth...

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Identifiers

PMID: 19074480
DOI: 10.1161/STROKEAHA.108.522284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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