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Article

Ultra-rapid droplet digital PCR enables intraoperative tumor quantification.

Med (New York, N.Y.) - 13 Jun 2025

Murphy Zachary R, Bianchini Emilia C, Smith Andrew, Körner Lisa I, Russell Teresa, Reinecke David, Maarouf Nader, Wang Yuxiu, Golfinos John G, Miller Alexandra M, Snuderl Matija, Orringer Daniel A, Evrony Gilad D

Abstract excerpt

BACKGROUND: The diagnosis and treatment of tumors often depend on molecular-genetic data. However, rapid and iterative access to molecular data is not currently feasible during surgery, complicating intraoperative diagnosis and precluding measurement of tumor cell burdens at surgical margins to guide resections. METHODS: Here, we introduce Ultra-Rapid droplet digital PCR (UR-ddPCR), a technology that achieves the...

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Identifiers

PMID: 40010345
DOI: 10.1016/j.medj.2025.100604
PMCID: PMC12167690

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BRAF
IDH1

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