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Article

TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2021

Muralidharan Koushik, Yekula Anudeep, Small Julia L, Rosh Zachary S, Kang Keiko M, Wang Lan, Lau Spencer, Zhang Hui, Lee Hakho, Bettegowda Chetan, Chicoine Michael R, Kalkanis Steven N, Shankar Ganesh M, Nahed Brian V, Curry William T, Jones Pamela S, Cahill Daniel P, Balaj Leonora, Carter Bob S

Abstract excerpt

PURPOSE: Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT promoter mutations (C228T, C250T) in cfDNA has been successful for some systemic cancers but has yet to be demonstrated in gliomas, despite the high prevalence of these mutations in glioma tissue (>60% of all tumors). EXPERIMENTAL DESIGN: Here, we...

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Identifiers

PMID: 33051308
DOI: 10.1158/1078-0432.CCR-20-3083
PMCID: PMC7785705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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