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Article

Human neutrophil antigen 3 genotype impacts neutrophil-mediated endothelial cell cytotoxicity in a two-event model of TRALI.

Blood transfusion = Trasfusione del sangue - 1 Nov 2022

Chiaretti Sara, Burton Mark, Hassel Penny, Radenkovic Filip, Devikashri Nilam, Sultana Annette J, Temple Fergal T, Dean Melinda M, Tung John-Paul

Abstract excerpt

BACKGROUND: Antibodies against human neutrophil antigen (HNA)-3a are associated with severe cases of transfusion-related acute lung injury (TRALI). The HNA-3 system is located on choline transporter-like 2 (CTL-2) protein. CTL-2 is encoded by the gene SLC44A2 and a single-nucleotide polymorphism c.461G>A results in two antigens: HNA-3a and HNA-3b. Three HNA-3 genotypes/ phenotypes exist: HNA-3aa, HNA-3bb, and...

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Identifiers

PMID: 35848624
DOI: 10.2450/2022.0013-22
PMCID: PMC9726621

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