Article
Anti-HNA testing of allo-exposed COVID-19 convalescent plasma donors including genetic human neutrophil antigen screening to prevent anti-HNA antibody-mediated transfusion-related acute lung injury.
Transfusion - 1 Sept 2024
Guz Katarzyna, Łopacz Patrycja, Uhrynowska Małgorzata, Piaskowska Karolina, Szczepaniak Beata, Krzemienowska Magdalena, Purchla-Szepioła Sylwia, Główka Anna, Głodkowska-Mrówka Eliza, Orzińska Agnieszka
Abstract excerpt
BACKGROUND: Transfusion-related acute lung injury caused by antibodies against human neutrophil antigens (HNA) is a serious but rare complication associated with blood transfusion. The presence of such antibodies is most probable in donors with a transfusion/pregnancy history. During the COVID-19 pandemic period convalescent plasma (CP) containing neutralizing antibodies against SARS-CoV-2 was widely used for...
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