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Article

Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies.

Blood - 18 Sept 2014

Storch Emily K, Hillyer Christopher D, Shaz Beth H

Abstract excerpt

Human neutrophil antigen-3a (HNA-3a) antibodies contained in donor plasma can result in severe, sometimes fatal transfusion-related acute lung injury (TRALI). Recent developments in TRALI secondary to antibodies to HNA-3a antigen span diagnosis, pathophysiology, treatment, and prevention resulting in improved understanding, potential treatments, and mitigation strategies. First, on the molecular level,...

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Identifiers

PMID: 25006121
DOI: 10.1182/blood-2014-05-538181

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