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Article

PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia

30 Oct 2021

Abstract excerpt

Mutations in the plant homeodomain-like finger protein 6 ( PHF6 ) gene are strongly associated with acute myeloid (AML) and T-cell acute lymphoblastic leukemia (T-ALL). In this study, we demonstrated that PHF6 can bind to H3K9me3 and H3K27me1 on the nucleolar chromatin and recruit histone methyltransferase SUV39H1 to the rDNA locus. The deletion of PHF6 caused a decrease in the recruitment of SUV39H1 to rDNA gene...

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Share to Acute Myeloid Leukemia Research
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Identifiers

PMID: 35847518
DOI: 10.1016/j.apsb.2021.10.025

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