Article
PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression.
Leukemia - 1 Feb 2022
Yuan Shengnan, Wang Xiaomin, Hou Shuaibing, Guo Tengxiao, Lan Yanjie, Yang Shuang, Zhao Fei, Gao Juan, Wang Yuxia, Chu Yajing, Shi Jun, Cheng Tao, Yuan Weiping
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematologic disease caused by gene mutations in T-cell progenitors. As an important epigenetic regulator, PHF6 mutations frequently coexist with JAK3 mutations in T-ALL patients. However, the role(s) of PHF6 mutations in JAK3-driven leukemia remain unclear. Here, the cooperation between JAK3 activation and PHF6 inactivation is examined in leukemia...
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