Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

23 Jun 2014

Abstract excerpt

BACKGROUND: Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Associations and Epidemiology
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24953961
DOI: 10.1186/1741-7015-12-103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic isletsPMID 24953961Read ↗

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.Semantic proximity Read ↗

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human IsletsSemantic proximity Read ↗

Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acidSemantic proximity Read ↗

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.Semantic proximity Read ↗

Thiol methyltransferase METTL7B coordinates lipid metabolism and promotes tumor progression in pancreatic cancerSemantic proximity Read ↗

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the HypothalamusSemantic proximity Read ↗

Epigenetic regulation of insulin action and secretion - role in the pathogenesis of type 2 diabetes.Semantic proximity Read ↗

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicitySemantic proximity Read ↗

Arachidonic and oleic acid exert distinct effects on the DNA methylomeSemantic proximity Read ↗

Fat, epigenome and pancreatic diseases. Interplay and common pathways from a toxic and obesogenic environmentSemantic proximity Read ↗

Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of EnhancersSemantic proximity Read ↗

Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.