Article
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Nature medicine - 1 Apr 2021
Zhou Sirui, Butler-Laporte Guillaume, Nakanishi Tomoko, Morrison David R, Afilalo Jonathan, Afilalo Marc, Laurent Laetitia, Pietzner Maik, Kerrison Nicola, Zhao Kaiqiong, Brunet-Ratnasingham Elsa, Henry Danielle, Kimchi Nofar, Afrasiabi Zaman, Rezk Nardin, Bouab Meriem, Petitjean Louis, Guzman Charlotte, Xue Xiaoqing, Tselios Chris, Vulesevic Branka, Adeleye Olumide, Abdullah Tala, Almamlouk Noor, Chen Yiheng, Chassé Michaël, Durand Madeleine, Paterson Clare, Normark Johan, Frithiof Robert, Lipcsey Miklós, Hultström Michael, Greenwood Celia M T, Zeberg Hugo, Langenberg Claudia, Thysell Elin, Pollak Michael, Mooser Vincent, Forgetta Vincenzo, Kaufmann Daniel E, Richards J Brent
Abstract excerpt
To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19...
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