Article

SARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease

2023-11-29

Abstract excerpt

The orphan gene of SARS-CoV-2, ORF10, is the least studied gene in the virus responsible for the COVID-19 pandemic. Recent experimentation indicated ORF10 expression moderates innate immunity in vitro. However, whether ORF10 affects COVID-19 in humans remained unknown. We determine that the ORF10 sequence is identical to the Wuhan-Hu-1 ancestral haplotype in 95% of genomes across five variants of concern (VOC). Fo...

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Literature Corpus work: ba6fc04b-45c9-56e1-b2d9-9f38e3696226
DOI: 10.1101/2023.11.27.23298847

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