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Article

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19.

Nature genetics - 1 Feb 2022

Huffman Jennifer E, Butler-Laporte Guillaume, Khan Atlas, Pairo-Castineira Erola, Drivas Theodore G, Peloso Gina M, Nakanishi Tomoko, Ganna Andrea, Verma Anurag, Baillie J Kenneth, Kiryluk Krzysztof, Richards J Brent, Zeberg Hugo

Abstract excerpt

The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping...

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Identifiers

PMID: 35027740
DOI: 10.1038/s41588-021-00996-8
PMCID: PMC8837537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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