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Article

The Functional OAS1 rs10774671A>G Variant Is Associated with COVID-19 Susceptibility in Mexican Patients.

International journal of molecular sciences - 25 Mar 2026

Montúfar-Robles Isela, Zapotitla-Román Blanca M, Vargas-Alarcón Gilberto, Fragoso José Manuel, Jiménez-Morales Silvia, Mendoza-Rincón Jorge Flavio, Cedro-Tanda Alberto, Barbosa-Cobos Rosa Elda, Rojas-Velazco Gustavo, Ramírez-Bello Julian

Abstract excerpt

OAS1 (2'-5'-oligoadenylate synthetase 1) and OAS3 have been identified through a genome-wide association study as major loci associated with COVID-19. The rs10774671A>G variant affects alternative splicing and generates two distinct mRNA and protein isoforms. The A allele produces the shorter p42 isoform, which has been associated with increased susceptibility, greater disease severity, and higher mortality from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41977153
DOI: 10.3390/ijms27072965
PMCID: PMC13073408

Genes

OAS1
OAS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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