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Article

De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma

22 Jul 2021

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide In multiple myeloma diseases, monoclonal immunoglobulin light chains (LCs) are abundantly produced, with, as a consequence in some cases, the formation of deposits affecting various organs, such as the kidney, while in other cases remaining soluble up to concentrations of several g·L –1 in plasma. The exact factors crucial for the solubility of LCs are poorly...

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PMID: 34292722
DOI: 10.1021/acs.analchem.1c01955

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