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Enhancing Molecular Network-Based Cancer Driver Gene Prediction Using Machine Learning Approaches: Current Challenges and Opportunities.

Journal of cellular and molecular medicine - 1 Jan 2025

Zhang Hao, Lin Chaohuan, Chen Ying'ao, Shen Xianrui, Wang Ruizhe, Chen Yiqi, Lyu Jie

Abstract excerpt

Cancer is a complex disease driven by mutations in the genes that play critical roles in cellular processes. The identification of cancer driver genes is crucial for understanding tumorigenesis, developing targeted therapies and identifying rational drug targets. Experimental identification and validation of cancer driver genes are time-consuming and costly. Studies have demonstrated that interactions among genes...

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PMID: 39804102
DOI: 10.1111/jcmm.70351
PMCID: PMC11726689

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