Integrating Protein-Protein Interaction Networks and Somatic Mutation Data to Detect Driver Modules in Pan-Cancer.

Abstract excerpt

With the constant update of large-scale sequencing data and the continuous improvement of cancer genomics data, such as International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), it gains increasing importance to detect the functional high-frequency mutation gene set in cells that causes cancer in the field of medicine. In this study, we propose a new recognition method of driver modules,...

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