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Article

Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes.

Nature communications - 12 Jul 2022

Vigué Lucile, Croce Giancarlo, Petitjean Marie, Ruppé Etienne, Tenaillon Olivier, Weigt Martin

Abstract excerpt

Characterizing the effect of mutations is key to understand the evolution of protein sequences and to separate neutral amino-acid changes from deleterious ones. Epistatic interactions between residues can lead to a context dependence of mutation effects. Context dependence constrains the amino-acid changes that can contribute to polymorphism in the short term, and the ones that can accumulate between species in...

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Identifiers

PMID: 35821377
DOI: 10.1038/s41467-022-31643-3
PMCID: PMC9276797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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