Epistasis and co-adaptation in bacterial genome evolution.

doi:10.1038/s41576-026-00941-7

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Article

Epistasis and co-adaptation in bacterial genome evolution.

Nature reviews. Genetics - 1 Jul 2026

Cummins Elizabeth A, Raikwar Priyanshu Singh, Hallett Eve, Sheppard Samuel K

Abstract excerpt

Precise genotype-phenotype mapping is essential in applied microbiology, from engineering genetically modified strains to developing tailored strategies for antimicrobial therapies. Comparative genomics often treats genes as independent contributors to phenotypes, and gene knockout and complementation remain the gold standard to validate genotype-phenotype associations in microorganisms. However, genes do not act...

Topics

Epistasis, Genetic
Genome, Bacterial
Evolution, Molecular
Bacteria
Adaptation, Physiological
Phenotype
Genomics

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Open in PubMed

Identifiers

PMID: 41772154
DOI: 10.1038/s41576-026-00941-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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