Article
p53 and p21 regulate error-prone DNA repair to yield a lower mutation load.
Molecular cell - 5 May 2006
Avkin Sharon, Sevilya Ziv, Toube Leanne, Geacintov Nicholas, Chaney Stephen G, Oren Moshe, Livneh Zvi
Abstract excerpt
Regulation of mutation rates is critical for maintaining genome stability and controlling cancer risk. A special challenge to this regulation is the presence of multiple mutagenic DNA polymerases in mammals. These polymerases function in translesion DNA synthesis (TLS), an error-prone DNA repair process that involves DNA synthesis across DNA lesions. We found that in mammalian cells TLS is controlled by the tumor...
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