Article
Targeted sequencing of candidate gene regions for myelofibrosis in dogs.
Journal of veterinary internal medicine - 1 Jul 2022
Campbell Amelia G, Seelig Davis M, Beckman Joan D, Minor Katie M, Heinrich Daniel A, Friedenberg Steven G, Modiano Jaime F, Furrow Eva
Abstract excerpt
BACKGROUND: Myelofibrosis often lacks an identifiable cause in dogs. In humans, most primary myelofibrosis cases develop secondary to driver mutations in JAK2, CALR, or MPL. OBJECTIVES: To determine the prevalence of variants in JAK2, CALR, or MPL candidate regions in dogs with myelofibrosis and in healthy dogs. ANIMALS: Twenty-six dogs with myelofibrosis that underwent bone marrow biopsy between 2010 and 2018...
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