Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Advances in understanding the pathogenesis of familial myeloproliferative neoplasms.

British journal of haematology - 1 Sept 2017

Rumi Elisa, Cazzola Mario

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are generally acquired as a result of a somatic stem cell mutation leading to clonal expansion of myeloid precursors. In addition to sporadic cases, familial MPN occurs when one or several MPN affect different relatives of the same family. MPN driver mutations (JAK2, CALR, MPL) are somatically acquired also in familial cases, so a genetic predisposition to acquire one of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CALR gene
Share to Genetic Predisposition to Disease
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematologic Neoplasms

Share to Myeloproliferative Disorders

Share to Pedigree

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 28444727
DOI: 10.1111/bjh.14713

Genes

CALR
GSKIP
JAK2
MPL
RBBP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Advances in understanding the pathogenesis of familial myeloproliferative neoplasms.PMID 28444727Read ↗

Germline genetic factors in the pathogenesis of myeloproliferative neoplasms.Semantic proximity Read ↗

Pathogenesis and management of high molecular risk myeloproliferative neoplasmsSemantic proximity Read ↗

Recent insights regarding the molecular basis of myeloproliferative neoplasms.Semantic proximity Read ↗

Molecular Pathogenesis of Myeloproliferative Neoplasms.Semantic proximity Read ↗

Inherited predisposition to myeloproliferative neoplasmsSemantic proximity Read ↗

Genetic Aspects of Myelodysplastic/Myeloproliferative NeoplasmsSemantic proximity Read ↗

[Recent advances in molecular pathogenesis of myeloproliferative neoplasms].Semantic proximity Read ↗

Familial MPN Predisposition.Semantic proximity Read ↗

Pathogenesis of Myeloproliferative DisordersSemantic proximity Read ↗

Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable.Semantic proximity Read ↗

Molecular Pathogenesis of Myeloproliferative Neoplasms: From Molecular Landscape to Therapeutic Implications.Semantic proximity Read ↗

Germline genetic variants that predispose to myeloproliferative neoplasms and hereditary myeloproliferative phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.