Article
Megakaryocytes in Myeloproliferative Neoplasms Have Unique Somatic Mutations.
The American journal of pathology - 1 Jul 2017
Guo Belinda B, Allcock Richard J, Mirzai Bob, Malherbe Jacques A, Choudry Fizzah A, Frontini Mattia, Chuah Hun, Liang James, Kavanagh Simon E, Howman Rebecca, Ouwehand Willem H, Fuller Kathryn A, Erber Wendy N
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are a group of related clonal hemopoietic stem cell disorders associated with hyperproliferation of myeloid cells. They are driven by mutations in the hemopoietic stem cell, most notably JAK2V617F, CALR, and MPL. Clinically, they have the propensity to progress to myelofibrosis and transform to acute myeloid leukemia. Megakaryocytic hyperplasia with abnormal features are...
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