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C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast.

DNA repair - 1 Sept 2022

Elsakrmy Noha, Aouida Mustapha, Hindi Nagham, Moovarkumudalvan Balasubramanian, Mohanty Ashima, Ali Reem, Ramotar Dindial

Abstract excerpt

Carcinogenicity and cytotoxicity are severe consequences of DNA damage. Base Excision Repair (BER) is a conserved DNA repair pathway that replaces many damaged bases caused by oxidation. Aberrations in BER are associated with carcinogenesis, neurodegeneration, and aging. The nematode C. elegans is an attractive model system for studying BER. However, in this organism, the complete pathway is not fully delineated....

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PMID: 35809390
DOI: 10.1016/j.dnarep.2022.103359

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