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Article

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice.

Molecular and cellular biology - 1 Dec 2005

Cui Xiaoping, Yu Yaping, Gupta Shikha, Cho Young-Moon, Lees-Miller Susan P, Meek Katheryn

Abstract excerpt

Two highly conserved double-strand break (DSB) repair pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), function in all eukaryotes. How a cell chooses which pathway to utilize is an area of active research and debate. During NHEJ, the DNA-dependent protein kinase (DNA-PK) functions as a "gatekeeper" regulating DNA end access. Here, we provide evidence that DNA-PK regulates DNA end...

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Identifiers

PMID: 16314509
DOI: 10.1128/MCB.25.24.10842-10852.2005
PMCID: PMC1316975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice.PMID 16314509Read ↗

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