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Article

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

25 Jun 2012

Abstract excerpt

To prevent accumulation of mutations, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homology-directed repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of ATR (ataxia telangiectasia mutated and Rad3 related) and CHK1 kinases to induce the cell cycle checkpoint. In this paper, we show that CHK1 was...

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PMID: 22733999
DOI: 10.1083/jcb.201111065

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CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiationPMID 22733999Read ↗

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Increased Resection at DSBs in G2-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.Semantic proximity Read ↗

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