Article
Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.
Scientific reports - 27 Jan 2020
Sakai Kensuke, Tanikawa Chizu, Hirasawa Akira, Chiyoda Tatsuyuki, Yamagami Wataru, Kataoka Fumio, Susumu Nobuyuki, Terao Chikashi, Kamatani Yoichiro, Takahashi Atsushi, Momozawa Yukihide, Hirata Makoto, Kubo Michiaki, Fuse Nobuo, Takai-Igarashi Takako, Shimizu Atsushi, Fukushima Akimune, Kadota Aya, Arisawa Kokichi, Ikezaki Hiroaki, Wakai Kenji, Yamaji Taiki, Sawada Norie, Iwasaki Motoki, Tsugane Shoichiro, Aoki Daisuke, Matsuda Koichi
Abstract excerpt
Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746 cases and 70,316 controls from the Japanese population, followed by a replication analysis using 3,483 cases and 4,795 controls. The analysis identified 9 significant loci, including a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.