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Article

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata.

Nature communications - 1 Feb 2023

Sliz Eeva, Tyrmi Jaakko S, Rahmioglu Nilufer, Zondervan Krina T, Becker Christian M, Uimari Outi, Kettunen Johannes

Abstract excerpt

Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36726022
DOI: 10.1038/s41467-023-35974-7
PMCID: PMC9892568

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