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Article

A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma.

PLoS genetics - 1 May 2024

Wu Xueyao, Xiao Changfeng, Rasooly Danielle, Zhao Xunying, Morton Cynthia Casson, Jiang Xia, Gallagher C Scott

Abstract excerpt

Age at first sexual intercourse (AFS) and lifetime number of sexual partners (NSP) may influence the pathogenesis of uterine leiomyoma (UL) through their associations with hormonal concentrations and uterine infections. Leveraging summary statistics from large-scale genome-wide association studies conducted in European ancestry for each trait (NAFS = 214,547; NNSP = 370,711; NUL = 302,979), we observed a...

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Source

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Identifiers

PMID: 38701081
DOI: 10.1371/journal.pgen.1011268
PMCID: PMC11095738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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