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Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review.

Journal of psychiatry & neuroscience : JPN - 1 Jul 2018

Soler Jordi, Fañanás Lourdes, Parellada Mara, Krebs Marie-Odile, Rouleau Guy A, Fatjó-Vilas Mar

Abstract excerpt

Scaffolding proteins represent an evolutionary solution to controlling the specificity of information transfer in intracellular networks. They are highly concentrated in complexes located in specific subcellular locations. One of these complexes is the postsynaptic density of the excitatory synapses. There, scaffolding proteins regulate various processes related to synaptic plasticity, such as glutamate receptor...

Topics

Autism Spectrum Disorder
Genetic Predisposition to Disease
Genetic Variation
Humans
Nerve Tissue Proteins
Schizophrenia

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29947605
DOI: 10.1503/jpn.170066
PMCID: PMC6019351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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