Article
Genomic map of candidate human imprint control regions: the imprintome.
Epigenetics - 1 Dec 2022
Jima Dereje D, Skaar David A, Planchart Antonio, Motsinger-Reif Alison, Cevik Sebnem E, Park Sarah S, Cowley Michael, Wright Fred, House John, Liu Andy, Jirtle Randy L, Hoyo Cathrine
Abstract excerpt
Imprinted genes - critical for growth, metabolism, and neuronal function - are expressed from one parental allele. Parent-of-origin-dependent CpG methylation regulates this expression at imprint control regions (ICRs). Since ICRs are established before tissue specification, these methylation marks are similar across cell types. Thus, they are attractive for investigating the developmental origins of adult...
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