SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.

Abstract excerpt

Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the SPRTN gene. Cells derived from patients with SPRTN mutations elicit genomic instability and people afflicted with this syndrome developed hepatocellular carcinoma. Here we describe the molecular mechanism by which SPRTN contributes to genome stability and normal cellular homeostasis. We show that SPRTN is a DNA-dependent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carcinoma, Hepatocellular
• Share to DNA-Binding Proteins