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Article

Random field modeling of multi-trait multi-locus association for detecting methylation quantitative trait loci.

Bioinformatics (Oxford, England) - 10 Aug 2022

Lyu Chen, Huang Manyan, Liu Nianjun, Chen Zhongxue, Lupo Philip J, Tycko Benjamin, Witte John S, Hobbs Charlotte A, Li Ming

Abstract excerpt

MOTIVATION: CpG sites within the same genomic region often share similar methylation patterns and tend to be co-regulated by multiple genetic variants that may interact with one another. RESULTS: We propose a multi-trait methylation random field (multi-MRF) method to evaluate the joint association between a set of CpG sites and a set of genetic variants. The proposed method has several advantages. First, it is a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35781319
DOI: 10.1093/bioinformatics/btac443
PMCID: PMC9364381

Genes

BACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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