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Article

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

Human molecular genetics - 15 Sept 2018

Richardson Tom G, Haycock Philip C, Zheng Jie, Timpson Nicholas J, Gaunt Tom R, Davey Smith George, Relton Caroline L, Hemani Gibran

Abstract excerpt

We have undertaken a systematic Mendelian randomization (MR) study using methylation quantitative trait loci (meQTL) as genetic instruments to assess the relationship between genetic variation, DNA methylation and 139 complex traits. Using two-sample MR, we identified 1148 associations across 61 traits where genetic variants were associated with both proximal DNA methylation (i.e. cis-meQTL) and complex trait...

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Identifiers

PMID: 29893838
DOI: 10.1093/hmg/ddy210
PMCID: PMC6121186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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