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Article

Detecting methylation quantitative trait loci using a methylation random field method.

Briefings in bioinformatics - 5 Nov 2021

Lyu Chen, Huang Manyan, Liu Nianjun, Chen Zhongxue, Lupo Philip J, Tycko Benjamin, Witte John S, Hobbs Charlotte A, Li Ming

Abstract excerpt

DNA methylation may be regulated by genetic variants within a genomic region, referred to as methylation quantitative trait loci (mQTLs). The changes of methylation levels can further lead to alterations of gene expression, and influence the risk of various complex human diseases. Detecting mQTLs may provide insights into the underlying mechanism of how genotypic variations may influence the disease risk. In this...

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PMID: 34414410
DOI: 10.1093/bib/bbab323
PMCID: PMC8575051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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