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Article

Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

3 Jul 2022

Abstract excerpt

In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. Here, we used the Collaborative Cross (CC) forward genetics mouse platform to identify modifier genes of neuronal hyperexcitation. We found LAMP5 as a novel regulator of hyperexcitation in mice, critical for the survival of...

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PMID: 35780436
DOI: 10.1007/s00401-022-02457-w

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