Article
Investigating how changes in the levels of kinesins impact neuronal health in Drosophila and human iPSC-derived neurons AD model.
Open biology - 13 May 2026
Francis Deepthy, Paonessa Francesco, Hewitt Victoria L, Southall Maria, Peset Isabel, Whitworth Alexander J, Livesey Frederick J, Fabre Caroline C G, Palacios Isabel M
Abstract excerpt
Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. Understanding the molecular pathology of AD may help identify new ways to reduce neuronal damage. In the past decades, Drosophila has become a powerful tool in modelling mechanisms underlying human diseases. Here, we investigate how the expression of the human 42-residue β-amyloid (Aβ) carrying the E22G...
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