Article
Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
Leukemia - 1 Aug 2022
Meyer Alison E, Stelloh Cary, Pulakanti Kirthi, Burns Robert, Fisher Joseph B, Heimbruch Katelyn E, Tarima Sergey, Furumo Quinlan, Brennan John, Zheng Yongwei, Viny Aaron D, Vassiliou George S, Rao Sridhar
Abstract excerpt
Acute myeloid leukemia (AML) is driven by mutations that occur in numerous combinations. A better understanding of how mutations interact with one another to cause disease is critical to developing targeted therapies. Approximately 50% of patients that harbor a common mutation in NPM1 (NPM1cA) also have a mutation in the cohesin complex. As cohesin and Npm1 are known to regulate gene expression, we sought to...
Topics
Join the communities discussing this publication.